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Cytotec misoprostol administration to women who are pregnant can cause birth defects, abortion, or premature birth.

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The results of clinical studies indicate that Cytotec does not produce hypotension at dosages effective in promoting the healing of gastric and duodenal ulcersNeverthelessCytotec should be used with caution in the presence of disease states where hypotension might precipitate severe complicationse.gcerebrovascular diseasecoronary artery disease or severe peripheral vascular disease including hypertension.

Cytotec should not be used in the third trimester in women with a history of Cesarean section or major uterine surgery because of an increased risk of uterine ruptureCytotec should not be used in cases where uterotonic drugs are generally contraindicated or where hyperstimulation of the uterus is considered inappropriatesuch as cephalopelvic disproportiongrand multiparityhypertonic or hyperactive uterine patternsor fetal distress where delivery is not imminentor when surgical intervention is more appropriate.

Diarrhea is common with misoprostol and usually occurs about two weeks after you start taking itand lasts for about a weekBe sure to keep up your intake of fluids and minerals/electrolytes to prevent dehydrationPersistent diarrhea may sometimes lead to a large loss of your body’s water and mineralsTell your doctor right away if you develop any of these serious signs of dehydration and mineral imbalancesevere dizzinessdecreased urinationmental/mood changesmuscle weaknessslow/irregular heartbeat.

Women of childbearing potential must be informed about the risk of teratogenicity prior to treatment with CytotecTreatment must not be initiated until pregnancy is excludedand women should be fully counselled on the importance of adequate contraception while undergoing treatmentIf pregnancy is suspectedtreatment must be immediately discontinuedsee sections 4.3 and 4.4

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